Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape
نویسندگان
چکیده
منابع مشابه
Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape
Ideally, disease modeling using patient-derived induced pluripotent stem cells (iPSCs) enables analysis of disease initiation and progression. This requires any pathological features of the patient cells used for reprogramming to be eliminated during iPSC generation. Hutchinson-Gilford progeria syndrome (HGPS) is a segmental premature aging disorder caused by the accumulation of the truncated f...
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During development, cell fate is specified precisely through programming by multiple complex elements and processes, including chromatin modifications that result in epigenetic marks. Once determined, cell fate is specified further only through maturation processes, which include differentiation and senescence. However, recent studies have shown that it is possible to influence cell fate throug...
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The demonstration of induced pluripotency and direct lineage conversion has led to remarkable insights regarding the roles of transcription factors and chromatin regulators in mediating cell state transitions. Beyond its considerable implications for regenerative medicine, this body of work is highly relevant to multiple stages of oncogenesis, from the initial cellular transformation to the hie...
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The epigenetic landscape [2] is a concept representing embryonic development. It was proposed by Conrad Hal Waddington [3] to illustrate the various developmental pathways a cell might take toward differentiation [4]. The epigenetic landscape [2] integrates the connected concepts of competence [5], induction [6], and regulative abilities of the genes [7] into a single model designed to explain ...
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Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAFs is largely unknown. In this study, we determined the contribution of miRNAs in the transformation of NFs into CAFs. We found that miR-1 and miR-206 were dow...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2017
ISSN: 1474-9718
DOI: 10.1111/acel.12621